176960-47-7
176960-47-7
Chemical Structure
BMS-193884
- CAS No.: 176960-47-7
- Formula:C20H17N3O4S
- Molecular Weight:395.43
IUPAC Name: N-(3,4-dimethylisoxazol-5-yl)-4'-(oxazol-2-yl)-[1,1'-biphenyl]-2-sulfonamide
InChIKey: LJGUZUROJOJEMI-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CC=C1C2=CC=C(C3=NC=CO3)C=C2)(NC4=C(C)C(C)=NO4)=O
Biological Activity: BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor[1].
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BMS-193884 | BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor. | |||||||||||||||||||||
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References
- [1]. Murugesan N, et al. Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. J Med Chem. 2003;46(1):125-137. [Content Brief]
