177583-70-9
Chemical Structure
ZK164015
- CAS No.: 177583-70-9
- Formula:C30H43NO4S
- Molecular Weight:513.73
IUPAC Name: 2-(4-hydroxyphenyl)-3-methyl-1-(10-(pentylsulfonyl)decyl)-1H-indol-5-ol
InChIKey: LYJSJVYJLZOMCD-UHFFFAOYSA-N
SMILES: OC1=CC2=C(N(CCCCCCCCCCS(=O)(CCCCC)=O)C(C3=CC=C(O)C=C3)=C2C)C=C1
Biological Activity: ZK164015 is an estrogen-glucocorticoid receptor chimera that can be used as a compound screening tool to evaluate tissue-selective estrogen activity. ZK164015 was used to evaluate its effects on ER function in osteoblasts in studies based on green fluorescent protein (GFP)-receptor chimeras. In osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cells, ZK164015 showed different effects in response to ER agonists, including modulation of ERE-luc activity and effects on nuclear mobility.
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ZK164015 | 99.94% | ZK164015 is an estrogen-glucocorticoid receptor chimera that can be used as a compound screening tool to evaluate tissue-selective estrogen activity. ZK164015 was used to evaluate its effects on ER function in osteoblasts in studies based on green fluorescent protein (GFP)-receptor chimeras. In osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cells, ZK164015 showed different effects in response to ER agonists, including modulation of ERE-luc activity and effects on nuclear mobility. | ||||||||||||||||||||
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