1781233-84-8
1781233-84-8
Chemical Structure
PAT-494
- CAS No.: 1781233-84-8
- Formula:C20H16FN3O2
- Molecular Weight:349.36
IUPAC Name: (R)-6-(4-fluorobenzyl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione
InChIKey: LRGAZQBFSHLAGN-QGZVFWFLSA-N
SMILES: O=C1NC(N2CC3=C(C4=CC=CC=C4N3CC5=CC=C(F)C=C5)C[C@@H]21)=O
Biological Activity: PAT-494 is an ATX inhibitor with significant activity in biochemical and plasma assays. PAT-494 can reduce LPA levels in rat plasma through oral administration. The structure-activity relationship study of PAT-494 shows that its binding mode with ATX is novel and it can effectively occupy the hydrophobic pockets and channels of ATX[1].
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PAT-494 | PAT-494 is an ATX inhibitor with significant activity in biochemical and plasma assays. PAT-494 can reduce LPA levels in rat plasma through oral administration. The structure-activity relationship study of PAT-494 shows that its binding mode with ATX is novel and it can effectively occupy the hydrophobic pockets and channels of ATX. | |||||||||||||||||||||
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