1781880-44-1
1781880-44-1
Chemical Structure
GABAA receptor agent 2 TFA
- CAS No.: 1781880-44-1
- Formula:C22H22F3N3O3
- Molecular Weight:433.42
IUPAC Name: 5-([1,1'-biphenyl]-3-yl)-4-(piperidin-4-yl)-1H-pyrazol-1-ol 2,2,2-trifluoroacetate
InChIKey: SULXXKLCQRXMHP-UHFFFAOYSA-N
SMILES: ON1N=CC(C2CCNCC2)=C1C3=CC(C4=CC=CC=C4)=CC=C3.OC(C(F)(F)F)=O
Biological Activity: GABAA receptor agent 2 TFA is a potent and high-affinity GABAA receptor antagonist with an IC50 of 24 nM (human α1β2γ2 GABAA-expressing tsA201 cells) and a Ki of 28 nM (rat GABAA receptors). GABAA receptor agent 2 TFA is inactive against four human GABA transporters (hGAT-1, hBGT-1, hGAT-2, and hGAT-3)[1].
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GABAA receptor agent 2 TFA | GABAA receptor agent 2 TFA is a potent and high-affinity GABAA receptor antagonist with an IC50 of 24 nM (human α1β2γ2 GABAA-expressing tsA201 cells) and a Ki of 28 nM (rat GABAA receptors). GABAA receptor agent 2 TFA is inactive against four human GABA transporters (hGAT-1, hBGT-1, hGAT-2, and hGAT-3). | |||||||||||||||||||||
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