1782-65-6
Chemical Structure
Hardwickiic acid
Synonym(s): (-)-Hardwickiic acid;(-)-Hardwikiic acid
- CAS No.: 1782-65-6
- Formula:C20H28O3
- Molecular Weight:316.43
IUPAC Name: (4aR,5S,6R,8aR)-5-(2-(furan-3-yl)ethyl)-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid
InChIKey: HHWOKJDCJVESIF-JBCDFXQESA-N
SMILES: C[C@]12[C@@](CCC=C2C(O)=O)([H])[C@](C)([C@H](C)CC1)CCC3=COC=C3
Biological Activity: Hardwickiic acid ((-)-Hardwickiic acid) is a diterpenoid compound. Hardwickiic acid can block tetrodotoxin-sensitive voltage-dependent sodium channels and possesses multiple activities such as insecticidal, antinociceptive, and neurotransmitter release-regulating effects. Hardwickiic acid can be used in the study of neurological diseases[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Hardwickiic acid | 99.91% | Hardwickiic acid ((-)-Hardwickiic acid) is a diterpenoid compound. Hardwickiic acid can block tetrodotoxin-sensitive voltage-dependent sodium channels and possesses multiple activities such as insecticidal, antinociceptive, and neurotransmitter release-regulating effects. Hardwickiic acid can be used in the study of neurological diseases. | ||||||||||||||||||||
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References
- [1]. Pittaluga A, et al. Effects of the neoclerodane Hardwickiic acid on the presynaptic opioid receptors which modulate noradrenaline and dopamine release in mouse central nervous system. Neurochem Int. 2013 Mar;62(4):354-9. [Content Brief]
- [2]. Bandara BM, et al. Isolation and Insecticidal Activity of (-)-Hardwickiic Acid from Croton aromaticus. Planta Med. 1987 Dec;53(6):575. [Content Brief]
- [3]. Cai S, et al. (-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 Mar 20;10(3):1716-1728. [Content Brief]
