17829-03-7
17829-03-7
Chemical Structure
7-Methylguanine-d3
- CAS No.: 17829-03-7
- Formula:C6H4D3N5O
- Molecular Weight:168.17
IUPAC Name: 2-amino-7-(methyl-d3)-3,7-dihydro-6H-purin-6-one
InChIKey: FZWGECJQACGGTI-FIBGUPNXSA-N
SMILES: O=C1C2=C(N=CN2C([2H])([2H])[2H])NC(N)=N1
Biological Activity: 7-Methylguanine-d3 is the deuterium labeled 7-Methylguanine[1]. 7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method[2].
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7-Methylguanine-d3 | 7-Methylguanine-d3 is the deuterium labeled 7-Methylguanine. 7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method. | |||||||||||||||||||||
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7-Methylguanine (Standard) | ≥98% | 7-Methylguanine (Standard) is the analytical standard of 7-Methylguanine (HY-113352). This product is intended for research and analytical applications. 7-Methylguanine is an orally active and competitive PARP-1 inhibitor with a Ki value of 61 μM. 7-Methylguanine is a metabolite of nucleic acids. 7-Methylguanine has anticancer activity against uterine sarcoma and colon adenocarcinoma. 7-Methylguanine is used as a probe for protein-DNA interactions. | ||||||||||||||||||||
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7-Methylguanine | 99.97% | 7-Methylguanine is an orally active and competitive PARP-1 inhibitor with a Ki value of 61 μM. 7-Methylguanine is a metabolite of nucleic acids. 7-Methylguanine has anticancer activity against uterine sarcoma and colon adenocarcinoma. 7-Methylguanine is used as a probe for protein-DNA interactions. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Lee S, et al. Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. J Am Chem Soc. 2008 Sep 3;130(35):11570-1. [Content Brief]
