178419-42-6
178419-42-6
Chemical Structure
AR-R17779 hydrochloride
- CAS No.: 178419-42-6
- Formula:C9H15ClN2O2
- Molecular Weight:218.68
IUPAC Name: (S)-4-azaspiro[bicyclo[2.2.2]octane-2,5'-oxazolidin]-2'-one hydrochloride
InChIKey: XGLBLUBBDSJBIU-FVGYRXGTSA-N
SMILES: O=C(NC1)O[C@@]21CN3CCC2CC3.[H]Cl
Biological Activity: AR-R17779 hydrochloride is a potent and selective full agonist of nAChR, with Kis of 92 and 16000 nM for α7 and α4β2 subtype, respectively. AR-R17779 hydrochloride can improve learning and memory in rats. AR-R17779 hydrochloride also has anxiolytic activity. AR-R17779 hydrochloride can reduce inflammation by activating antiinflammatory cholinergic (vagal) pathways[1][2][4].
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AR-R17779 hydrochloride | 99.0% | AR-R17779 hydrochloride is a potent and selective full agonist of nAChR, with Kis of 92 and 16000 nM for α7 and α4β2 subtype, respectively. AR-R17779 hydrochloride can improve learning and memory in rats. AR-R17779 hydrochloride also has anxiolytic activity. AR-R17779 hydrochloride can reduce inflammation by activating antiinflammatory cholinergic (vagal) pathways. | ||||||||||||||||||||
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References
- [1]. Mullen G, et, al. (-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. J Med Chem. 2000 Nov 2;43(22):4045-50. [Content Brief]
- [2]. Levin ED, et, al. AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats. Behav Pharmacol. 1999 Nov;10(6-7):675-80. [Content Brief]
- [4]. Lopes F, et, al. Involvement of Mast Cells in α7 Nicotinic Receptor Agonist Exacerbation of Freund's Complete Adjuvant-Induced Monoarthritis in Mice. [Content Brief]
