178946-89-9
178946-89-9
Chemical Structure
C-DIM12
Synonym(s): DIM-C-pPhCl
- CAS No.: 178946-89-9
- Formula:C23H17ClN2
- Molecular Weight:356.85
IUPAC Name: 3,3'-((4-chlorophenyl)methylene)bis(1H-indole)
InChIKey: LTLRXTDMXOFBDW-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1
Biological Activity: C-DIM12 is a potent, orally active Nurr1 modulator. C-DIM12 inhibits the tumor growth and autophagy, and induces the cell apoptosis. C-DIM12 has anti-inflammatory and neuroprotective effects, and can be used for cancer and neurological disease study[1][2][3].
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C-DIM12 | 98.01% | C-DIM12 is a potent, orally active Nurr1 modulator. C-DIM12 inhibits the tumor growth and autophagy, and induces the cell apoptosis. C-DIM12 has anti-inflammatory and neuroprotective effects, and can be used for cancer and neurological disease study. | ||||||||||||||||||||
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References
- [1]. Zarei M, et al. Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma. Cancer Res Commun. 2021;1(2):65-78. [Content Brief]
- [2]. Sean L. Hammond, et al. The Nurr1 Ligand,1,1-bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism. J Pharmacol Exp Ther. 2018 Jun; 365(3): 636–651.
- [3]. Keita Kinoshita, et al. A Nurr1 ligand C-DIM12 attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice. Sci Rep. 2022; 12: 11009.
