1790089-97-2
1790089-97-2
Chemical Structure
LXRα agonist 1
- CAS No.: 1790089-97-2
- Formula:C28H27N3O2
- Molecular Weight:437.53
InChIKey: XNAXGNVKNMAHSV-UHFFFAOYSA-N
SMILES: O=C(C(C1=CC=CC=C1)=C2NC3=CC=C(N4CCCCC4)C=C3)N(CC5=CC=CC=C5)C2=O
Biological Activity: LXRα agonist 1 is a selective LXRα agonist, with EC50 values of 42 nM and 266 nM against purified LXRα and LXRβ, respectively. LXRα agonist 1 acts as a lipotoxicity inducer, triggering the production of toxic saturated fatty acids in tumor cells, and induces lipotoxicity-mediated cancer cell death when combined with the Raf inhibitor Sorafenib (HY-10201). LXRα agonist 1 can be used in the research of hepatocellular carcinoma[1].
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LXRα agonist 1 | LXRα agonist 1 is a selective LXRα agonist, with EC50 values of 42 nM and 266 nM against purified LXRα and LXRβ, respectively. LXRα agonist 1 acts as a lipotoxicity inducer, triggering the production of toxic saturated fatty acids in tumor cells, and induces lipotoxicity-mediated cancer cell death when combined with the Raf inhibitor Sorafenib (HY-10201). LXRα agonist 1 can be used in the research of hepatocellular carcinoma. | |||||||||||||||||||||
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