1793052-96-6
1793052-96-6
Chemical Structure
SRS16-86
- CAS No.: 1793052-96-6
- Formula:C26H32N4O2
- Molecular Weight:432.56
IUPAC Name: tert-butyl 4-(((3s,5s,7s)-adamantan-1-yl)amino)-3-(((Z)-pyrimidin-5-ylmethylene)amino)benzoate
InChIKey: DFENTOUMMDWZAF-WFRXSUHXSA-N
SMILES: O=C(C1=CC(/N=C\C2=CN=CN=C2)=C(C=C1)NC3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3)OC(C)(C)C
Biological Activity: SRS16-86 is a potent inhibitor of ferroptosis[1]. SRS16-86 is more stable than more stable to metabolism and plasma than Ferrostatin-1 in vivo. SRS16-86 can be used for renal ischemia-reperfusion injury (IRI) and spinal cord injury (SCI) research[2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SRS16-86 | 98.0% | SRS16-86 is a potent inhibitor of ferroptosis. SRS16-86 is more stable than more stable to metabolism and plasma than Ferrostatin-1 in vivo. SRS16-86 can be used for renal ischemia-reperfusion injury (IRI) and spinal cord injury (SCI) research. | ||||||||||||||||||||
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References
- [1]. Sam Hofmans, et al. Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties. J Med Chem. 2016 Mar 10;59(5):2041-53. [Content Brief]
- [2]. Andreas Linkermann, et al. Synchronized renal tubular cell death involves ferroptosis.Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16836-41. [Content Brief]
- [3]. Yan Zhang, et al. Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury. Brain Res. 2019 Mar 1;1706:48-57. [Content Brief]
