179333-18-7
Chemical Structure
NGD 94-1 dimaleate
- CAS No.: 179333-18-7
- Formula:C26H28N6O8
- Molecular Weight:552.54
IUPAC Name: 2-(4-((2-phenyl-1H-imidazol-5-yl)methyl)piperazin-1-yl)pyrimidine dimaleate
InChIKey: CEFBXMNJODPQHJ-SPIKMXEPSA-N
SMILES: O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.C1(N2CCN(CC3=CN=C(C4=CC=CC=C4)N3)CC2)=NC=CC=N1
Biological Activity: NGD 94-1 (dimaleate) is a potent and selective dopamine D4 receptor antagonist. NGD 94-1 (dimaleate) shows high affinity for the cloned human D4.2 receptor (Ki = 3.6 nM). NGD 94-1 (dimaleate) modulates the cognitive functions of the frontostriatal system and regulates dopaminergic transmission in Phencyclidine (PCP)-induced monkeys. NGD 94-1 (dimaleate) can be used for neurological disease research[1][2].
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NGD 94-1 dimaleate | NGD 94-1 (dimaleate) is a potent and selective dopamine D4 receptor antagonist. NGD 94-1 (dimaleate) shows high affinity for the cloned human D4.2 receptor (Ki = 3.6 nM). NGD 94-1 (dimaleate) modulates the cognitive functions of the frontostriatal system and regulates dopaminergic transmission in Phencyclidine (PCP)-induced monkeys. NGD 94-1 (dimaleate) can be used for neurological disease research. | |||||||||||||||||||||
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