1794812-00-2
Chemical Structure
YM-60828-d3
- CAS No.: 1794812-00-2
- Formula:C27H28D3N5O5S
- Molecular Weight:613.57
IUPAC Name: 2-(N-((7-carbamimidoylnaphthalen-2-yl)methyl)-N-(4-((1-(1-iminoethyl-2,2,2-d3)piperidin-4-yl)oxy)phenyl)sulfamoyl)acetic acid
InChIKey: NPBKHEMDWREFJJ-FIBGUPNXSA-N
SMILES: N(CC1=CC2=C(C=C1)C=CC(C(=N)N)=C2)(S(CC(O)=O)(=O)=O)C3=CC=C(OC4CCN(C(C([2H])([2H])[2H])=N)CC4)C=C3
Biological Activity: YM-60828-d3 is the deuterium labeled YM-60828 (HY-10280). YM-60828 is an orally active, selective and competitive factor Xa inhibitor with a Ki of 1.3 nM and an IC50 of 2.3 nM. YM-60828 inhibits thrombus formation and platelet aggregation. YM-60828 can be used for the research of venous thrombosis, arterial thrombosis, and thromboembolic disorders[1][2][3][4][5].
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YM-60828-d3 | YM-60828-d3 is the deuterium labeled YM-60828 (HY-10280). YM-60828 is an orally active, selective and competitive factor Xa inhibitor with a Ki of 1.3 nM and an IC50 of 2.3 nM. YM-60828 inhibits thrombus formation and platelet aggregation. YM-60828 can be used for the research of venous thrombosis, arterial thrombosis, and thromboembolic disorders. | |||||||||||||||||||||
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References
- [1]. Sato K, et al. Antithrombotic effects of YM-60828 in three thrombosis models in guinea pigs. Eur J Pharmacol. 1998;350(1):87-91. [Content Brief]
- [2]. Hirayama F, et al. The discovery of YM-60828: a potent, selective and orally-bioavailable factor Xa inhibitor. Bioorg Med Chem. 2002;10(5):1509-1523. [Content Brief]
- [3]. Kawasaki T, et al. Effect of a synthetic factor Xa inhibitor, YM-60828, on blood vessel patency in combination with a thrombolytic agent and on blood loss from the operation site in a rat model of arterial thrombosis. Thromb Haemost. 1998;79(4):859-864. [Content Brief]
- [4]. Kawasaki T, et al. Comparative studies of an orally-active factor Xa inhibitor, YM-60828, with other antithrombotic agents in a rat model of arterial thrombosis. Thromb Haemost. 1998;79(2):410-416. [Content Brief]
- [5]. Taniuchi Y, et al. Biochemical and pharmacological characterization of YM-60828, a newly synthesized and orally active inhibitor of human factor Xa. Thromb Haemost. 1998;79(3):543-548. [Content Brief]
