17969-20-9
17969-20-9
Chemical Structure
Fenclozic acid
Synonym(s): ICI-54450; Acidum fenclozicum; Mialex
- CAS No.: 17969-20-9
- Formula:C11H8ClNO2S
- Molecular Weight:253.70
IUPAC Name: 2-(2-(4-chlorophenyl)thiazol-4-yl)acetic acid
InChIKey: APBSKHYXXKHJFK-UHFFFAOYSA-N
SMILES: O=C(O)CC1=CSC(C2=CC=C(Cl)C=C2)=N1
Biological Activity: Fenclozic acid (ICI-54450) is an orally active anti-inflammatory, analgesic, and antipyretic agent. Fenclozic acid exhibits anti-inflammatory activity in Edadjuvant-induced arthritis and Carrageenin-induced oedema in rats. Fenclozic acid can be used for the research of arthritis[1][2][3].
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Fenclozic acid | 99.52% | Fenclozic acid (ICI-54450) is an orally active anti-inflammatory, analgesic, and antipyretic agent. Fenclozic acid exhibits anti-inflammatory activity in Edadjuvant-induced arthritis and Carrageenin-induced oedema in rats. Fenclozic acid can be used for the research of arthritis. | ||||||||||||||||||||
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References
- [1]. Curtis CG, et al. The fate of fenclozic acid in the gut and its effect on some aspects of gut metabolism. Xenobiotica. 1983;13(8):483-496. [Content Brief]
- [2]. Newbould BB, et al. The pharmacology of fenclozic acid (2-(4-chlorophenyl)-thiazol-4-ylacetic acid; I.C.I. 54,450; 'Myalex'); a new compound with anti-inflammatory, analgesic and antipyretic activityl. Br J Pharmacol. 1969;35(3):487-497. [Content Brief]
- [3]. Martin S, et al. Identification of the reactive metabolites of fenclozic acid in bile duct cannulated rats. Anal Chem. 2014;86(22):11281-11289. [Content Brief]
