1801187-61-0
Chemical Structure
N3-CMC
- CAS No.: 1801187-61-0
- Formula:C21H32N6O4S
- Molecular Weight:464.58
IUPAC Name: 4-(2-(((S)-(((1s,4R)-4-azidocyclohexyl)imino)methylene)amino)ethyl)-4-methylmorpholin-4-ium 4-methylbenzenesulfonate
InChIKey: YXSXASYTJMFBOJ-KAECKJJSSA-M
SMILES: C[N+]1(CCN=[C@@]=N[C@H]2CC[C@@H](N=[N+]=[N-])CC2)CCOCC1.O=S(C3=CC=C(C)C=C3)([O-])=O
Biological Activity: N3-CMC is a click chemistry reagent. N3-CMC containing an azide group can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. N3-CMC can also undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. N3-CMC reacts specifically with the pseudouridine (Ψ)-containing RNA, and biotin is subsequently conjugated to the N3-CMC-Ψ RNA via click chemistry, quantitatively analyzing the dynamic changes of Ψ[1].
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N3-CMC | N3-CMC is a click chemistry reagent. N3-CMC containing an azide group can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. N3-CMC can also undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. N3-CMC reacts specifically with the pseudouridine (Ψ)-containing RNA, and biotin is subsequently conjugated to the N3-CMC-Ψ RNA via click chemistry, quantitatively analyzing the dynamic changes of Ψ. | |||||||||||||||||||||
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