1801372-27-9
1801372-27-9
Chemical Structure
APX879
- CAS No.: 1801372-27-9
- Formula:C46H73N3O12
- Molecular Weight:860.08
InChIKey: SNUGJLTYIQECPY-OZIGKTPASA-N
SMILES: CO[C@@H]1[C@]2([H])O[C@]([C@@H](C1)C)(C(C(N3[C@](CCCC3)([H])C(O[C@@H]([C@@H]([C@H](C/C([C@@H](/C=C(C[C@@H](C[C@@H]2OC)C)\C)CC=C)=N/NC(C)=O)O)C)/C(C)=C/[C@H]4C[C@H]([C@@H](CC4)O)OC)=O)=O)=O)O
Biological Activity: APX879 is a fungal-specific calcineurin inhibitor that has less immunosuppressive activities and toxicities. APX879 is a C22-modified FK506 (HY-13756) analog, which maintains broad-spectrum antifungal activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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APX879 | 95.36% | APX879 is a fungal-specific calcineurin inhibitor that has less immunosuppressive activities and toxicities. APX879 is a C22-modified FK506 (HY-13756) analog, which maintains broad-spectrum antifungal activity. | ||||||||||||||||||||
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References
- [1]. Gobeil SM, et al. Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. mBio. 2021 Dec 21;12(6):e0300021. [Content Brief]
- [2]. Hoy M J. Development of Novel Antifungal Compounds for the Treatment of Systemic Fungal Infections[D]. Duke University, 2022.
