1801903-15-0
1801903-15-0
Chemical Structure
Vps34-IN-5
- CAS No.: 1801903-15-0
- Formula:C22H17ClF2N6O2S
- Molecular Weight:502.92
InChIKey: XBKWBMYYORYTID-UHFFFAOYSA-N
SMILES: O=S(NC1=C(N=CC(C2=CC(NC3=NC(C)=NC=C3)=NC=C2)=C1C)Cl)(C4=CC=C(C=C4F)F)=O
Biological Activity: Vps34-IN-5 is an orally active VPS34 inhibitor, 98% target inhibition, and an IC50 categorized as B. Vps34-IN-5 induces additive or synergistic anti-proliferative activity with EGFR inhibitors in cancer cells. Vps34-IN-5 is administered orally alone or with Erlotinib (HY-50896) in mouse xenograft models. Vps34-IN-5 can be used for the research of non-small cell lung cancer[1].
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Vps34-IN-5 | Vps34-IN-5 is an orally active VPS34 inhibitor, 98% target inhibition, and an IC50 categorized as B. Vps34-IN-5 induces additive or synergistic anti-proliferative activity with EGFR inhibitors in cancer cells. Vps34-IN-5 is administered orally alone or with Erlotinib (HY-50896) in mouse xenograft models. Vps34-IN-5 can be used for the research of non-small cell lung cancer. | |||||||||||||||||||||
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