1802013-08-6
1802013-08-6
Chemical Structure
ITH12575
- CAS No.: 1802013-08-6
- Formula:C18H18ClNOS
- Molecular Weight:331.86
IUPAC Name: 7-chloro-5-(2-isopropylphenyl)-1,5-dihydrobenzo[e][1,4]thiazepin-2(3H)-one
InChIKey: RDMUJSJZBYAAEF-UHFFFAOYSA-N
SMILES: O=C1NC2=CC=C(Cl)C=C2C(C3=CC=CC=C3C(C)C)SC1
Biological Activity: ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca2+ influx through CALHM1 at low micromolar concentrations[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ITH12575 | 98.84% | ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca2+ influx through CALHM1 at low micromolar concentrations. | ||||||||||||||||||||
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References
- [1]. Francisco J Martínez-Sanz, et al. Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration. ACS Chem Neurosci. 2015 Sep 16;6(9):1626-36. [Content Brief]
- [2]. Ana J Moreno-Ortega, et al. Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca2+ entry through CALHM1. Neuropharmacology. 2015 Aug;95:503-10. [Content Brief]
