1802326-66-4
1802326-66-4
Chemical Structure
JNJ-63533054
- CAS No.: 1802326-66-4
- Formula:C17H17ClN2O2
- Molecular Weight:316.78
IUPAC Name: (S)-3-chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl)benzamide
InChIKey: MWDVCHRYCKXEBY-LBPRGKRZSA-N
SMILES: O=C(NCC(N[C@H](C1=CC=CC=C1)C)=O)C2=CC=CC(Cl)=C2
Biological Activity: JNJ-63533054 is a potent, selective and orally active GPR139 agonist with an EC50 of 16 nM for human GPR139 (hGPR139). JNJ-63533054 shows selective for GPR139 over other GPCRs, ion channels, and transporters. JNJ-63533054 can cross the blood-brain barrier (BBB)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JNJ-63533054 | 99.80% | JNJ-63533054 is a potent, selective and orally active GPR139 agonist with an EC50 of 16 nM for human GPR139 (hGPR139). JNJ-63533054 shows selective for GPR139 over other GPCRs, ion channels, and transporters. JNJ-63533054 can cross the blood-brain barrier (BBB). | ||||||||||||||||||||
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References
- [1]. Liu C, et al. GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine. Mol Pharmacol. 2015 Nov;88(5):911-25. [Content Brief]
- [2]. Dvorak CA, et al. Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8. [Content Brief]
