1805781-73-0
Chemical Structure
GN-2 peptoid
- CAS No.: 1805781-73-0
- Formula:C78H110N18O9
- Molecular Weight:1443.82
InChIKey: BXCPTDLPMBKJDA-UHFFFAOYSA-N
SMILES: CCC(N(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CN(C(CNCCCCN)=O)CCC1=CNC2=C1C=CC=C2)=O)CCCCN)=O)CCCCN)=O)CCC3=CNC4=C3C=CC=C4)=O)CCC5=CNC6=C5C=CC=C6)=O)CCCCN)=O)CCC7=CNC8=C7C=CC=C8)=O)CC(N)=O)C
Biological Activity: GN-2 peptoid is a 9-mer cationic amphipathic peptoid and bactericidal agent with an overall net charge of +4, broad-spectrum antimicrobial activity, and low hemolytic and cytotoxic activity against mammalian cells. GN-2 peptoid exerts bactericidal action against Escherichia coli in a concentration-dependent manner. GN-2 peptoid exhibits antimicrobial activity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, Pseudomonas aeruginosa strains. GN-2 peptoid shows low toxicity against human red blood cells and HeLa cells. GN-2 peptoid maintains antimicrobial activity in the presence of 50% human blood plasma. GN-2 peptoid can be used for the research of bacterial infections[1].
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GN-2 peptoid | GN-2 peptoid is a 9-mer cationic amphipathic peptoid and bactericidal agent with an overall net charge of +4, broad-spectrum antimicrobial activity, and low hemolytic and cytotoxic activity against mammalian cells. GN-2 peptoid exerts bactericidal action against Escherichia coli in a concentration-dependent manner. GN-2 peptoid exhibits antimicrobial activity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, Pseudomonas aeruginosa strains. GN-2 peptoid shows low toxicity against human red blood cells and HeLa cells. GN-2 peptoid maintains antimicrobial activity in the presence of 50% human blood plasma. GN-2 peptoid can be used for the research of bacterial infections. | |||||||||||||||||||||
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