1807353-31-6
Chemical Structure
Dios-Arg diTFA
- CAS No.: 1807353-31-6
- Formula:C43H67F6N5O9
- Molecular Weight:912.01
IUPAC Name: (4S,5'R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl 6-((S)-2-amino-5-guanidinopentanamido)hexanoate bis(2,2,2-trifluoroacetate)
InChIKey: BUBYULRFSQOIII-XWXJGKJWSA-N
SMILES: [H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](OC(CCCCCNC([C@@H](N)CCCNC(N)=N)=O)=O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H].O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Biological Activity: Dios-Arg diTFA, a cationic lipid with an arginine-bearing headgroup, shows obvious double bond proton signals at around 5.2-5.3 ppm. Dios-Arg diTFA is used, coupled to DOPE, to bind siRNA and plasmid to for cationic LNPs for intracellular transport[1][2].
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Dios-Arg diTFA | Dios-Arg diTFA, a cationic lipid with an arginine-bearing headgroup, shows obvious double bond proton signals at around 5.2-5.3 ppm. Dios-Arg diTFA is used, coupled to DOPE, to bind siRNA and plasmid to for cationic LNPs for intracellular transport. | |||||||||||||||||||||
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References
- [1]. Ruilong Sheng, et al. Cationic Nanoparticles Assembled from Natural-Based Steroid Lipid for Improved Intracellular Transport of siRNA and pDNA. Nanomaterials (Basel). 2016 Apr 13;6(4):69. [Content Brief]
- [2]. Ruilong Sheng, et al. Skeleton-Controlled pDNA Delivery of Renewable Steroid-Based Cationic Lipids, the Endocytosis Pathway Analysis and Intracellular Localization. Int J Mol Sci. 2018 Jan 26;19(2):369. [Content Brief]
