1807758-81-1
1807758-81-1
Chemical Structure
SIRT7 inhibitor 97491
- CAS No.: 1807758-81-1
- Formula:C15H12ClN3O
- Molecular Weight:285.73
IUPAC Name: N1-(5-(4-chlorophenyl)oxazol-2-yl)benzene-1,3-diamine
InChIKey: RMRVZWMKRCLSFX-UHFFFAOYSA-N
SMILES: NC1=CC(NC2=NC=C(C3=CC=C(Cl)C=C3)O2)=CC=C1
Biological Activity: SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.[1].
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SIRT7 inhibitor 97491 | 98.81% | SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.. | ||||||||||||||||||||
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