1807847-98-8
Chemical Structure
THP-NCS
- CAS No.: 1807847-98-8
- Formula:C66H74N10O10S2
- Molecular Weight:1231.48
InChIKey: QNJZPMOAYGHWKR-UHFFFAOYSA-N
SMILES: O=C1C=C(C)N(C)C(CNC(CCC(CCC(NCC2=C(C(C=C(C)N2C)=O)OCC3=CC=CC=C3)=O)(CCC(NCC4=C(C(C=C(C)N4C)=O)OCC5=CC=CC=C5)=O)NC(CCNC(NC6=CC=C(C=C6)N=C=S)=S)=O)=O)=C1OCC7=CC=CC=C7
Biological Activity: THP-NCS is a bifunctional chelator bearing an isothiocyanate group, enabling radiolabeling. THP-NCS can conjugate antibody fragments for gallium isotope radiolabeling in ImmunoPET imaging. THP-NCS can conjugate biomolecules, including cyclic RGD peptides. THP-NCS can conjugate PEGylated liposomes or bone-targeting aminobisphosphonates via thiourea bonds for metal chelation pretargeting[1][2][3].
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THP-NCS | THP-NCS is a bifunctional chelator bearing an isothiocyanate group, enabling radiolabeling. THP-NCS can conjugate antibody fragments for gallium isotope radiolabeling in ImmunoPET imaging. THP-NCS can conjugate biomolecules, including cyclic RGD peptides. THP-NCS can conjugate PEGylated liposomes or bone-targeting aminobisphosphonates via thiourea bonds for metal chelation pretargeting. | |||||||||||||||||||||
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References
- [1]. Cusnir R, et al. Hydroxypyridinone Chelators: From Iron Scavenging to Radiopharmaceuticals for PET Imaging with Gallium-68. International journal of molecular sciences. 2017 Jan 08;18(1):116.
- [2]. Obregon-Perko V, et al. Dynamics and origin of rebound viremia in SHIV-infected infant macaques following interruption of long-term ART. JCI insight. 2021 Dec 08;6(23):e152526.
- [3]. Mishra A, et al. Exploring In Vivo Metal Chelation as an Approach for Pretargeted PET Imaging. ACS omega. 2025 May 20;10(19):19379-19393.
