1808297-63-3
Chemical Structure
ProTx-III
Synonym(s): μ-TRTX-Tp1a
- CAS No.: 1808297-63-3
- Formula:C162H246N52O43S6
- Molecular Weight:3802.40
SMILES: O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)[C@H](CC)C)=O)CC4=CNC=N4)=O)CC(C)C)=O)CCCCN)=O)=O)CCCCN)=O)CC(O)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CCC1)=O)CC(N)=O)=O)CSSC[C@H](NC5=O)C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CC6=CNC7=CC=CC=C67)=O)CC(N)=O)=O)CC8=CNC=N8)=O)CC(N)=O)=O)CO)=O)=O)=O)CCCCN)=O)CC9=CNC%10=CC=CC=C9%10)=O)=O)CC%11=CC=CC=C%11)=O)CCCCN)=O)CC(C)C)=O)CSSC[C@H](NC2=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H]5CCCCN)=O)CC(C)C)=O)=O)CO)=O
Biological Activity: ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia[1].
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ProTx-III | ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia. | |||||||||||||||||||||
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