181217-39-0
181217-39-0
Chemical Structure
Fenoldopam hydrochloride
Synonym(s): SKF 82526 hydrochloride
- CAS No.: 181217-39-0
- Formula:C16H17Cl2NO3
- Molecular Weight:342.22
IUPAC Name: 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrochloride
InChIKey: NLMPGIXLXSPNFS-UHFFFAOYSA-N
SMILES: ClC1=C(CCNCC2C3=CC=C(C=C3)O)C2=CC(O)=C1O.Cl
Biological Activity: Fenoldopam (SKF 82526) hydrochloride is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam hydrochloride shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis[1][2][3].
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Fenoldopam hydrochloride | Fenoldopam (SKF 82526) hydrochloride is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam hydrochloride shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis. | |||||||||||||||||||||
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References
- [1]. A Grenader, et al. Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther. 1991 Jul 1;258(1):193-8. [Content Brief]
- [2]. Yan Zheng, et al. Identification of fenoldopam as a novel LSD1 inhibitor to abrogate the proliferation of renal cell carcinoma using drug repurposing strategy. Bioorg Chem. 2021 Mar;108:104561. [Content Brief]
- [3]. Yuta Fujii, et al. Detection of fenoldopam-induced arteritis in rats using ex vivo / in vivo MRI. Toxicology Reports, Volume 9, 2022, Pages 1595-1602.
