181225-33-2
Chemical Structure
Ginsenoside F4
- CAS No.: 181225-33-2
- Formula:C42H70O12
- Molecular Weight:767.00
IUPAC Name: (2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-((E)-6-methylhepta-2,5-dien-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyra
InChIKey: QOMBXPYXWGTFNR-PWAOTOFHSA-N
SMILES: C[C@]12[C@]3([C@@]([C@H](O)C[C@]1([H])[C@@]4([C@@](C(C)([C@@H](O)CC4)C)([H])[C@@H](O[C@@]5([H])[C@@H]([C@H]([C@H](O)[C@@H](CO)O5)O)O[C@@]6([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O6)O)O)C2)C)([H])[C@@H](/C(C)=C/C/C=C(C)/C)CC3)C
Biological Activity: Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis[1]. Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ginsenoside F4 | 98.54% | Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis. Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues. | ||||||||||||||||||||
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Damulin A | 98.42% | Damulin A is a saponin found in G. pentaphyllum with anti-cancer activities. | ||||||||||||||||||||
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Ginsenoside Rf | 99.48% | Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel. | ||||||||||||||||||||
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Ginsenoside Rg2 | 98.71% | Ginsenoside Rg2 is one of the major active components of ginseng. Ginsenoside Rg2 inhibits VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS). Ginsenoside Rg2 also reduces Aβ1-42 accumulation. | ||||||||||||||||||||
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Ginsenoside Rh4 | 99.28% | Ginsenoside Rh4 is a rare saponin obtained from Panax notoginseng. Ginsenoside Rh4 activates Bax, caspase 3, caspase 8, and caspase 9. Ginsenoside Rh4 also induces autophagy. | ||||||||||||||||||||
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Ginsenoside Rg6 | 99.87% | Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC50 of 29.34 μM in HepG2 cells. Ginsenoside Rg6 also exhibits apoptosis-inducing effect. | ||||||||||||||||||||
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Ginsenoside Rg5 (Standard) | ≥98% | Ginsenoside Rg5 (Standard) is the analytical standard of Ginsenoside Rg5. This product is intended for research and analytical applications. Ginsenoside Rg5 is the main component of Red ginseng and IGF-1R agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of IGF-1 to IGF-1R (IC50 about 90 nM). Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65. | ||||||||||||||||||||
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20(22Z)-Ginsenoside Rh4 | 20(22Z)-Ginsenoside Rh4 is a rare ginsenoside with antitumor, anti-inflammation, and anti-diabetic activities.20(22Z)-Ginsenoside Rh4 can be found in Panax ginseng. | |||||||||||||||||||||
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20(R)-Ginsenoside Rg2 (Standard) | ≥98% | 20(R)-Ginsenoside Rg2 (Standard) is the analytical standard of 20(R)-Ginsenoside Rg2. This product is intended for research and analytical applications. 20(R)-Ginsenoside Rg2 shows inhibitory effects on lung cancer NCI-H1650 cells. Anti-cancer activities. | ||||||||||||||||||||
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Ginsenoside Rg4 | 99.94% | Ginsenoside Rg4 is an orally active protopanaxatriol type ginsenoside. Ginsenoside Rg4 can activate PI3K, AKT and GSK-3β signaling. Ginsenoside Rg4 can inhibit ROS and inflammatory cytokine levels. Ginsenoside Rg4 can be used for the researches of inflammation, infection and metabolic disease, such as sepsis and lung inflammation. | ||||||||||||||||||||
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Notoginsenoside T5 | 95.0% | Notoginsenoside T5 is a dammarane 61 glycoside. Notoginsenoside T5 is isolated from the acidic deglycosylation of saponins from the roots of P. 62 notoginseng. | ||||||||||||||||||||
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References
- [1]. Chen B, et al. The apoptosis-inducing effect of ginsenoside F4 from steamed notoginseng on human lymphocytoma JK cells. Nat Prod Res. 2013;27(24):2351-4. [Content Brief]
- [2]. Lee JH, et al. Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation. Eur J Pharmacol. 2014 Feb 5;724:145-51. [Content Brief]
