1821484-84-7
Chemical Structure
TrkA-IN-23
- CAS No.: 1821484-84-7
- Formula:C26H23Cl2N5O3
- Molecular Weight:524.40
IUPAC Name: 5-(2,4-dichloro-5-(pyridin-2-yl)benzamido)-N-(2-hydroxy-2-methylpropyl)-1-phenyl-1H-pyrazole-3-carboxamide
InChIKey: NXDRKVFQQJUBOG-UHFFFAOYSA-N
SMILES: O=C(NCC(O)(C)C)C1=NN(C=2C=CC=CC2)C(=C1)NC(=O)C3=CC(=C(Cl)C=C3Cl)C4=NC=CC=C4
Biological Activity: TrkA-IN-23 is an allosteric, orally active, selective TrkA inhibitor with an IC50 of 4 nM. TrkA-IN-23 inhibits NGF-induced phosphorylated ERK formation. TrkA-IN-23 reverses thermal hyperalgesia and eliminates Capsaicin (HY-10448) sensitization in NGF-sensitized skin. TrkA-IN-23 can be used for research on inflammatory diseases[1].
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TrkA-IN-23 | TrkA-IN-23 is an allosteric, orally active, selective TrkA inhibitor with an IC50 of 4 nM. TrkA-IN-23 inhibits NGF-induced phosphorylated ERK formation. TrkA-IN-23 reverses thermal hyperalgesia and eliminates Capsaicin (HY-10448) sensitization in NGF-sensitized skin. TrkA-IN-23 can be used for research on inflammatory diseases. | |||||||||||||||||||||
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