1822358-25-7
Chemical Structure
POL1-IN-1
- CAS No.: 1822358-25-7
- Formula:C21H20N6
- Molecular Weight:356.42
IUPAC Name: 2-((3R,5S)-3,5-dimethylpiperazin-1-yl)benzo[4,5]imidazo[1,2-a][1,8]naphthyridine-6-carbonitrile
InChIKey: HFQPEPQECNSOFF-OKILXGFUSA-N
SMILES: N#CC1=CC2=C(N3C1=NC4=CC=CC=C43)N=C(N5C[C@@H](C)N[C@@H](C)C5)C=C2
Biological Activity: POL1-IN-1 is a class of RNA polymerase I inhibitors with broad-spectrum antiproliferative activity against tumor cells, while selectively inhibiting RNA polymerase I transcription. By blocking RNA polymerase I-mediated rRNA synthesis, POL1-IN-1 impairs ribosome biogenesis, thereby inhibiting tumor cell proliferation and inducing apoptosis. POL1-IN-1 can be used for the research of malignant tumors[1].
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POL1-IN-1 | 98.05% | POL1-IN-1 is a class of RNA polymerase I inhibitors with broad-spectrum antiproliferative activity against tumor cells, while selectively inhibiting RNA polymerase I transcription. By blocking RNA polymerase I-mediated rRNA synthesis, POL1-IN-1 impairs ribosome biogenesis, thereby inhibiting tumor cell proliferation and inducing apoptosis. POL1-IN-1 can be used for the research of malignant tumors. | ||||||||||||||||||||
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