1825345-52-5
Chemical Structure
AZ0108
- CAS No.: 1825345-52-5
- Formula:C24H20F4N6O2
- Molecular Weight:500.45
IUPAC Name: (S)-4-((3-(3-(1,1-difluoroethyl)-6-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)phenyl)difluoromethyl)phthalazin-1(2H)-one
InChIKey: NWGMIELHSCQGOG-ZDUSSCGKSA-N
SMILES: O=C(C1=CC(C(F)(C(C2=CC=CC=C23)=NNC3=O)F)=CC=C1)N4CC5=NN=C(C(F)(C)F)N5C[C@@H]4C
Biological Activity: AZ0108 is an inhibitor for poly ADP-ribose polymerase (PARP), which inhibits PARP1, PARP2, PARP3, PARP6, TNKS1, TNKS2, with IC50s of <0.03, <0.03, 2.8, 0.083, 3.2, >3 μM, respectively. AZ0108 prevents centrosome clustering with an EC50 of 0.053 μM, and exhibits cytotoxicity in cell OCI-LY-19 with GI50 of 0.017 μM. AZ0108 exhibits good in vivo pharmacokinetic characters in rat/mouse models[1].
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AZ0108 | AZ0108 is an inhibitor for poly ADP-ribose polymerase (PARP), which inhibits PARP1, PARP2, PARP3, PARP6, TNKS1, TNKS2, with IC50s of <0.03, <0.03, 2.8, 0.083, 3.2, >3 μM, respectively. AZ0108 prevents centrosome clustering with an EC50 of 0.053 μM, and exhibits cytotoxicity in cell OCI-LY-19 with GI50 of 0.017 μM. AZ0108 exhibits good in vivo pharmacokinetic characters in rat/mouse models. | |||||||||||||||||||||
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