182912-74-9
Chemical Structure
β-Sheet Breaker Peptide iAβ5
Synonym(s): [Pro18, Asp21] β-Amyloid (17-21)
- CAS No.: 182912-74-9
- Formula:C33H43N5O8
- Molecular Weight:637.72
IUPAC Name: L-leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-aspartic acid
InChIKey: RALAXQOLLAQGTI-IRGGMKSGSA-N
SMILES: OC(C[C@@H](C(O)=O)NC([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CC=CC=C2)NC([C@H]3N(CCC3)C([C@@H](N)CC(C)C)=O)=O)=O)=O)=O
Biological Activity: β-Sheet Breaker Peptide iAβ5 ([Pro18, Asp21] β-Amyloid (17-21)) is an amyloid fibril disaggregation inducer. β-Sheet Breaker Peptide iAβ5 inhibits fibril formation and disaggregates preformed fibrils by binding to the central hydrophobic region of Aβ (LVFFA) and disrupting the interactions between Aβ monomers/oligomers. β-Sheet Breaker Peptide iAβ5 reproducibly induces the disaggregation of fibrillar amyloid deposits in rat brain. β-Sheet Breaker Peptide iAβ5 prevents and reverses Aβ-induced neuronal shrinkage, reduces IL-1β-positive microglia surrounding Aβ deposits, and decreases the size of cerebral amyloid plaques. β-Sheet Breaker Peptide iAβ5 labeled with HBA enables blue quantitative detection under acidic conditions. β-Sheet Breaker Peptide iAβ5 is used in research related to Alzheimer's disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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β-Sheet Breaker Peptide iAβ5 | 98.64% | β-Sheet Breaker Peptide iAβ5 ([Pro18, Asp21] β-Amyloid (17-21)) is an amyloid fibril disaggregation inducer. β-Sheet Breaker Peptide iAβ5 inhibits fibril formation and disaggregates preformed fibrils by binding to the central hydrophobic region of Aβ (LVFFA) and disrupting the interactions between Aβ monomers/oligomers. β-Sheet Breaker Peptide iAβ5 reproducibly induces the disaggregation of fibrillar amyloid deposits in rat brain. β-Sheet Breaker Peptide iAβ5 prevents and reverses Aβ-induced neuronal shrinkage, reduces IL-1β-positive microglia surrounding Aβ deposits, and decreases the size of cerebral amyloid plaques. β-Sheet Breaker Peptide iAβ5 labeled with HBA enables blue quantitative detection under acidic conditions. β-Sheet Breaker Peptide iAβ5 is used in research related to Alzheimer's disease. | ||||||||||||||||||||
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References
- [1]. Soto C, et al. Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy. Nature medicine. 1998 Jul;4(7):822-6. [Content Brief]
- [2]. Sigurdsson EM, et al. In vivo reversal of amyloid-beta lesions in rat brain. Journal of neuropathology and experimental neurology. 2000 Jan;59(1):11-7. [Content Brief]
- [3]. Okada Y, et al. Acid-Triggered Colorimetric Hydrophobic Benzyl Alcohols for Soluble Tag-Assisted Liquid-Phase Synthesis. Organic letters. 2015 Sep 04;17(17):4264-7. [Content Brief]
