183012-13-7
183012-13-7
Chemical Structure
YM116
- CAS No.: 183012-13-7
- Formula:C16H13N3
- Molecular Weight:247.29
IUPAC Name: 2-((1H-imidazol-5-yl)methyl)-9H-carbazole
InChIKey: SHWQRVBJVFBWGP-UHFFFAOYSA-N
SMILES: C1(NC2=C3C=CC=C2)=C3C=CC(CC4=CN=CN4)=C1
Biological Activity: YM116 is an orally active and competitive CYP17A1 (17,20-lyase) inhibitor (Ki: 0.38 nM). YM116 reduces the synthesis of adrenal androgens by preferentially inhibiting C17-20 lyase activity. YM116 decreases the serum testosterone concentration, reduces dehydroepiandrosterone sulfate levels and decreases prostatic weights[1][2].
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YM116 | YM116 is an orally active and competitive CYP17A1 (17,20-lyase) inhibitor (Ki: 0.38 nM). YM116 reduces the synthesis of adrenal androgens by preferentially inhibiting C17-20 lyase activity. YM116 decreases the serum testosterone concentration, reduces dehydroepiandrosterone sulfate levels and decreases prostatic weights. | |||||||||||||||||||||
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References
- [1]. Ideyama Y, et al. Novel nonsteroidal inhibitor of cytochrome P450(17alpha) (17alpha-hydroxylase/C17-20 lyase), YM116, decreased prostatic weights by reducing serum concentrations of testosterone and adrenal androgens in rats. Prostate. 1998 Sep 15;37(1):10-8. [Content Brief]
- [2]. Ideyama Y, et al. YM116, 2-(1H-imidazol-4-ylmethyl)-9H-carbazole, decreases adrenal androgen synthesis by inhibiting C17-20 lyase activity in NCI-H295 human adrenocortical carcinoma cells. Jpn J Pharmacol. 1999 Feb;79(2):213-20. [Content Brief]
