1830306-93-8
1830306-93-8
Chemical Structure
Giffonin P
- CAS No.: 1830306-93-8
- Formula:C19H22O7
- Molecular Weight:362.37
IUPAC Name: (4R,5S,7S,8S)-1,2(1,3)-dibenzenacyclononaphane-16,26,4,5,6,7,8-heptaol
InChIKey: ITCMVFGYPKRCJI-YMNIQUSHSA-N
SMILES: OC(C=C1)=C(C=C1C[C@H]([C@@H](C2O)O)O)C(C=C3C[C@@H]([C@@H]2O)O)=C(C=C3)O
Biological Activity: Giffonin P is a selective inhibitor targeting α-glucosidase with an IC50 of 55.3 μM. Giffonin P delays carbohydrate hydrolysis and glucose absorption, exerting anti-hyperglycemic activity. Giffonin P reduces postprandial blood glucose levels and is primarily used in research on type 2 diabetes[1][2].
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Giffonin P | Giffonin P is a selective inhibitor targeting α-glucosidase with an IC50 of 55.3 μM. Giffonin P delays carbohydrate hydrolysis and glucose absorption, exerting anti-hyperglycemic activity. Giffonin P reduces postprandial blood glucose levels and is primarily used in research on type 2 diabetes. | |||||||||||||||||||||
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References
- [1]. Masullo M, et al. Giffonins J-P, Highly Hydroxylated Cyclized Diarylheptanoids from the Leaves of Corylus avellana Cultivar "Tonda di Giffoni". J Nat Prod. 2015 Dec 24;78(12):2975-82. [Content Brief]
- [2]. Masullo M, et al. Corylus avellana: A Source of Diarylheptanoids With α-Glucosidase Inhibitory Activity Evaluated by in vitro and in silico Studies. Front Plant Sci. 2022 Feb 14;13:805660. [Content Brief]
