1831085-48-3
1831085-48-3
Chemical Structure
Gumelutamide
- CAS No.: 1831085-48-3
- Formula:C22H21ClN6O
- Molecular Weight:420.89
IUPAC Name: 2-chloro-4-(4-((5-(2-hydroxypropan-2-yl)pyridin-2-yl)amino)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)benzonitrile
InChIKey: TYOPGJVWUJIKHX-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(N2CC3=C(CC2)C(NC4=NC=C(C(C)(C)O)C=C4)=NC=N3)C=C1Cl
Biological Activity: Gumelutamide is a tetrahydropyridopyrimidine compound, acting as an antiandrogen, antineoplastic agent. Gumelutamide is an androgen antagonist[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Gumelutamide | 99.00% | Gumelutamide is a tetrahydropyridopyrimidine compound, acting as an antiandrogen, antineoplastic agent. Gumelutamide is an androgen antagonist. | ||||||||||||||||||||
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PD-307243 | 96.50% | PD-307243 is a hERG channel activator. PD-307243 can be used for research of arrhythmias. | ||||||||||||||||||||
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JNJ-38893777 | JNJ-38893777 is an orally active and highly selective transient receptor potential vanilloid type 1 (TRPV1) channel antagonist. JNJ-38893777 inhibits neuronal hyperactivation and reduces inflammatory hyperalgesia. JNJ-38893777 is promising for research of migraine headaches, neuropathic and inflammatory pain. | |||||||||||||||||||||
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RS 2232 | RS 2232 is an orally active, competitive 5-HT deamination inhibitor with a Ki of 0.054 μM. RS-2232 exhibits reversible and specific inhibition of type A monoamine oxidase. RS 2232 can be used in brain research. | |||||||||||||||||||||
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PDE5-IN-6c | PDE5-IN-6c is a potent and selective phosphodiesterase 5A1 (PDE5A1) inhibitor with the potential to inhibit Alzheimer's disease (AD). PDE5-IN-6c exhibits an excellent in vitro IC50 (0.056 nM), demonstrating its potent inhibitory activity. PDE5-IN-6c has improved water solubility, making it a more attractive drug candidate. | |||||||||||||||||||||
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CDK6/9-IN-1 | CDK6/9-IN-1 (compound 66) is an orally active active and dual CDK 6 and CDK 9 inhibitor, with IC50 values of 40.5 nM and 39.5 nM for CDK6 anmd CDK9, respectively. | |||||||||||||||||||||
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ATX inhibitor 5 | 98.71% | ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC50 of 15.3 nM. ATX inhibitor 5 shows anti-hepatofibrosis effects and reduces CCl4-induced hepatic fibrosis level prominently. | ||||||||||||||||||||
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ATX inhibitor 18 | ATX inhibitor 18 is a potent ATX inhibitor with an IC50 value of 24.2 nM. ATX inhibitor 18 shows antiproliferative activity and anti-fibrosis activity. ATX inhibitor 18 suppresses collagen deposition in TGF-β-mediated cardiac fibrosis. | |||||||||||||||||||||
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ROS1-IN-1 | ROS1-IN-1 (Compound 31) is a potent and selective ROS1 kinase inhibitor with an IC50 of 0.097 μM. | |||||||||||||||||||||
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Gumelutamide monosuccinate | Gumelutamide (monosuccinate) is a tetrahydropyridopyrimidine compound, acting as an antiandrogen, antineoplastic agent. Gumelutamide (monosuccinate) is an androgen antagonist. | |||||||||||||||||||||
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AR ligand-44 | AR ligand-44 is an androgen receptor ligand that can be used in the synthesis of PROTACs, such as ARD-2051 (HY-149862). | |||||||||||||||||||||
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