1831135-46-6
Chemical Structure
ABC44
- CAS No.: 1831135-46-6
- Formula:C31H40N6O5
- Molecular Weight:576.69
IUPAC Name: 7-((1-benzylpiperidin-4-yl)methyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 4-(4-methoxyphenyl)piperazine-1-carboxylate
InChIKey: YHRQLTHMALGXOG-UHFFFAOYSA-N
SMILES: O=C(N1CCN(C2=CC=C(OC)C=C2)CC1)ON(C3=O)C(N4C3CN(CC5CCN(CC6=CC=CC=C6)CC5)CC4)=O
Biological Activity: ABC44 is a potent serine hydrolase inhibitor, with IC50 values of 0.1 μM (HEK293T in situ), 6.5 μM (HEK293T in vitro), and 1.26 μM (cell-free enzymatic assay) against palmitoyl-protein thioesterase 1 (PPT1). ABC44 can be used for research on late infantile neuronal ceroid lipofuscinosis and cancer[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ABC44 | 98.7% | ABC44 is a potent serine hydrolase inhibitor, with IC50 values of 0.1 μM (HEK293T in situ), 6.5 μM (HEK293T in vitro), and 1.26 μM (cell-free enzymatic assay) against palmitoyl-protein thioesterase 1 (PPT1). ABC44 can be used for research on late infantile neuronal ceroid lipofuscinosis and cancer. | ||||||||||||||||||||
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References
- [1]. Puhl AC, et al. Identification of New Modulators and Inhibitors of Palmitoyl-Protein Thioesterase 1 for CLN1 Batten Disease and Cancer. ACS omega. 2024 Mar 12;9(10):11870-11882. [Content Brief]
- [2]. Cognetta AB, et al. Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases. Chemistry & biology. 2015 Jul 23;22(7):928-37. [Content Brief]
- [3]. Won SJ, et al. Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle. ACS chemical biology. 2018 Jun 15;13(6):1560-1568. [Content Brief]
- [4]. Ross MK, et al. Expanding the Toolkit for the Serine Hydrolases. Chemistry & biology. 2015 Jul 23;22(7):808-9.
