183283-19-4
Chemical Structure
EDMPC
- CAS No.: 183283-19-4
- Formula:C38H77NO8P+
- Molecular Weight:706.99
InChIKey: GQOBJNOATQOLJE-IFPPELDOSA-N
SMILES: C[N+](C)(C)CCOP(OC[C@@H](COC(CCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCC)=O)(OCC)=O
Biological Activity: EDMPC is a cationic lipid that efficiently mediates the transmembrane and intracellular delivery of nucleic acids and proteins. EDMPC encapsulates nucleic acids through electrostatic interactions to form lipoplexes, thereby protecting nucleic acids from enzymatic degradation in vivo and effectively promoting their endocytosis and uptake by cells. EDMPC can be used in research on cystic fibrosis, melanoma, and breast cancer[1][2][3][4][5][6][7][8].
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EDMPC | EDMPC is a cationic lipid that efficiently mediates the transmembrane and intracellular delivery of nucleic acids and proteins. EDMPC encapsulates nucleic acids through electrostatic interactions to form lipoplexes, thereby protecting nucleic acids from enzymatic degradation in vivo and effectively promoting their endocytosis and uptake by cells. EDMPC can be used in research on cystic fibrosis, melanoma, and breast cancer. | |||||||||||||||||||||
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References
- [1]. Noone PG, et al. Safety and biological efficacy of a lipid–CFTR complex for gene transfer in the nasal epithelium of adult patients with cystic fibrosis. Molecular Therapy. 2000 Jan 1;1(1):105-14.
- [2]. Ferrari S, et al. Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium. Gene therapy. 2001 Sep;8(18):1380-6.
- [3]. Toyofuku K, et al. Non-Invasive Transdermal Delivery of Antisense Oligonucleotides with Biocompatible Ionic Liquids. ACS applied materials & interfaces. 2023 Jul 19;15(28):33299-33308.
- [4]. Zhang Y, et al. Lipids and Lipid Derivatives for RNA Delivery. Chemical reviews. 2021 Oct 27;121(20):12181-12277.
- [5]. Cui L, et al. Macromolecule-Loaded Hybrid Extracellular Vesicles via Ionic Lipid-Based Post-Loading for Intracellular Delivery: Functional Evaluation for Neurodegenerative Therapy. Journal of extracellular biology. 2026 Mar;5(3):e70125.
- [6]. Sarker MS, et al. Needle-free transdermal delivery of lipid-based ionic liquid-mediated laminarin-loaded solid-in-oil nanodispersion for enhanced antibody response. Chem Lett. 2026;55:upag127.
- [7]. Lonez C, et al. Cationic lipid nanocarriers activate Toll-like receptor 2 and NLRP3 inflammasome pathways. Nanomedicine : nanotechnology, biology, and medicine. 2014 May;10(4):775-82.
- [8]. Gorman CM, et al. Efficient in vivo delivery of DNA to pulmonary cells using the novel lipid EDMPC. Gene therapy. 1997 Sep;4(9):983-92. [Content Brief]
