183509-24-2
183509-24-2
Chemical Structure
17(R)-HETE
- CAS No.: 183509-24-2
- Formula:C20H32O3
- Molecular Weight:320.47
IUPAC Name: (R,5Z,8Z,11Z,14Z)-17-hydroxyicosa-5,8,11,14-tetraenoic acid
InChIKey: OPPIPPRXLIDJKN-DWUYYRGZSA-N
SMILES: CCC[C@@H](O)C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
Biological Activity: 17R-HETE is an arachidonic acid metabolite through cytochrome P-450 pathways. 17R-HETE exhibits efficacy in inducing cardic hypertrophy with less efficiency with compared to 17S-HETE[1][2].
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17(R)-HETE | 17R-HETE is an arachidonic acid metabolite through cytochrome P-450 pathways. 17R-HETE exhibits efficacy in inducing cardic hypertrophy with less efficiency with compared to 17S-HETE. | |||||||||||||||||||||
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References
- [1]. Carroll MA, et al., Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. Am J Physiol. 1996 Oct;271(4 Pt 2):R863-9. [Content Brief]
- [2]. Isse FA, et al., 17-(R/S)-hydroxyeicosatetraenoic acid (HETE) induces cardiac hypertrophy through the CYP1B1 in enantioselective manners. Prostaglandins Other Lipid Mediat. 2023 Oct;168:106749. [Content Brief]
