1846570-40-8
1846570-40-8
Chemical Structure
CM-579
- CAS No.: 1846570-40-8
- Formula:C29H40N4O3
- Molecular Weight:492.65
IUPAC Name: 6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine
InChIKey: VMMRDFLDWHFNOX-UHFFFAOYSA-N
SMILES: CN1CCC(CNC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1
Biological Activity: CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].
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CM-579 | CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells. | |||||||||||||||||||||
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