18508-77-5
18508-77-5
Chemical Structure
Illudalic acid
- CAS No.: 18508-77-5
- Formula:C15H16O5
- Molecular Weight:276.28
InChIKey: BDEDPKFUFGCVCJ-UHFFFAOYSA-N
SMILES: CC1(CC2=C(C(C=O)=C3CC(OC(C3=C2C1)=O)O)O)C
Biological Activity: Illudalic acid is a sesquiterpenoid natural product discovered in Omphalotus illudens. Illudalic acid inhibits LAR with an IC50 of 2.1 µM, and also inhibits CD45, PTPμ, and SHP2. Illudalic acid derivatives inhibit PTPRD and reduce drug-induced reward behavior in animal models. Illudalic acid can be used in research on LAR-related diseases[1][2][3][4].
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Illudalic acid | Illudalic acid is a sesquiterpenoid natural product discovered in Omphalotus illudens. Illudalic acid inhibits LAR with an IC50 of 2.1 µM, and also inhibits CD45, PTPμ, and SHP2. Illudalic acid derivatives inhibit PTPRD and reduce drug-induced reward behavior in animal models. Illudalic acid can be used in research on LAR-related diseases. | |||||||||||||||||||||
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References
- [1]. Uhl GR, et al. Selecting the appropriate hurdles and endpoints for pentilludin, a novel antiaddiction pharmacotherapeutic targeting the receptor type protein tyrosine phosphatase D. Frontiers in psychiatry. 2023;14:1031283.
- [2]. Uhl GR, et al. Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist. Proceedings of the National Academy of Sciences of the United States of America. 2018 Nov 06;115(45):11597-11602. [Content Brief]
- [3]. McCullough BS, et al. Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions. Journal of natural products. 2019 Dec 27;82(12):3386-3393.
- [4]. Ling Q, et al. Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. Bioorganic & medicinal chemistry. 2008 Aug 01;16(15):7399-409. [Content Brief]
