185351-23-9
185351-23-9
Chemical Structure
Cl-NQTrp
- CAS No.: 185351-23-9
- Formula:C21H15ClN2O4
- Molecular Weight:394.81
IUPAC Name: (3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-L-tryptophan
InChIKey: ZKNQSBBALRSDBQ-INIZCTEOSA-N
SMILES: ClC(C(C1=C(C=CC=C1)C2=O)=O)=C2N[C@H](C(O)=O)CC3=CNC4=C3C=CC=C4
Biological Activity: Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cl-NQTrp | 99.97% | Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein. | ||||||||||||||||||||
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References
- [1]. V Guru KrishnaKumar, et al. Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids. Sci Rep. 2018 Jan 8;8(1):71. [Content Brief]
- [2]. Moran Frenkel-Pinter, et al. Cl-NQTrp Alleviates Tauopathy Symptoms in a Model Organism through the Inhibition of Tau Aggregation-Engendered Toxicity. Neurodegener Dis. 2017;17(2-3):73-82. [Content Brief]
