1858291-14-1
Chemical Structure
(3S,4S)-PF-06459988
- CAS No.: 1858291-14-1
- Formula:C19H22ClN7O3
- Molecular Weight:431.88
IUPAC Name: 1-((3S,4S)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one
InChIKey: ODMXWZROLKITMS-SMDDNHRTSA-N
SMILES: C=CC(N1C[C@@H](COC2=C3C(NC=C3Cl)=NC(NC4=CN(C)N=C4)=N2)[C@H](OC)C1)=O
Biological Activity: (3S, 4S)-PF-06459988 is the S enantiomer of PF-06459988 with less active. PF-06459988 is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). PF-06459988 has excellent selectivity against EGFR wild-type while possessing a minimally reactive electrophile that reduces the propensity of off-target labeling[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(3S,4S)-PF-06459988 | 98.97% | (3S, 4S)-PF-06459988 is the S enantiomer of PF-06459988 with less active. PF-06459988 is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). PF-06459988 has excellent selectivity against EGFR wild-type while possessing a minimally reactive electrophile that reduces the propensity of off-target labeling. | ||||||||||||||||||||
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