185844-12-6
Chemical Structure
DSPE-PEG2000-Maleimide free acid
- CAS No.: 185844-12-6
- Formula:N/A
- Molecular Weight:2000 (average)
InChIKey: COHBSWQJIOSMAN-QZNUWAOFSA-N
SMILES: O=C1C=CC(N1CCC(NCCOCCOC(NCCOP(OC[C@@](OC(CCCCCCCCCCCCCCCCC)=O)([H])COC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O)=O)=O.[n]
Biological Activity: DSPE-PEG2000-Maleimide free acid is a phospholipid-PEG conjugate. DSPE-PEG2000-Maleimide free acid utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. DSPE-PEG2000-Maleimide free acid covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. DSPE-PEG2000-Maleimide free acid can be used in the researches of breast cancer, lymphoma, and inherited retinal degeneration[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DSPE-PEG2000-Maleimide free acid | 99.70% | DSPE-PEG2000-Maleimide free acid is a phospholipid-PEG conjugate. DSPE-PEG2000-Maleimide free acid utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. DSPE-PEG2000-Maleimide free acid covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. DSPE-PEG2000-Maleimide free acid can be used in the researches of breast cancer, lymphoma, and inherited retinal degeneration. | ||||||||||||||||||||
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References
- [1]. Nallamothu R, et al. A targeted liposome delivery system for combretastatin A4: formulation optimization through drug loading and in vitro release studies. PDA J Pharm Sci Technol. 2006;60(3):144-155. [Content Brief]
- [2]. Gao J, et al. The promotion of siRNA delivery to breast cancer overexpressing epidermal growth factor receptor through anti-EGFR antibody conjugation by immunoliposomes. Biomaterials. 2011;32(13):3459-3470. [Content Brief]
- [3]. Ishida T, et al. A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs. FEBS Lett. 1999 Oct 22;460(1):129-33. [Content Brief]
- [4]. Herrera-Barrera M, et al. Peptide-guided lipid nanoparticles deliver mRNA to the neural retina of rodents and nonhuman primates. Sci Adv. 2023 Jan 13;9(2):eadd4623. [Content Brief]
