1859-42-3
1859-42-3
Chemical Structure
KNK423
- CAS No.: 1859-42-3
- Formula:C12H11NO3
- Molecular Weight:217.22
IUPAC Name: (E)-3-(benzo[d][1,3]dioxol-5-ylmethylene)pyrrolidin-2-one
InChIKey: IJPPHWXYOJXQMV-WEVVVXLNSA-N
SMILES: O=C1NCC/C1=C\C2=CC=C3OCOC3=C2
Biological Activity: KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research[1][2].
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KNK423 | KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research. | |||||||||||||||||||||
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References
- [1]. Koishi M, et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res. 2001 Jan;7(1):215-9. [Content Brief]
- [2]. Blatzer M, et al. Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains. Antimicrob Agents Chemother. 2015 Jul;59(7):3778-88. [Content Brief]
