186046-82-2
Chemical Structure
Fmoc-PNA-A(Bhoc)-OH
- CAS No.: 186046-82-2
- Formula:C40H35N7O7
- Molecular Weight:725.75
IUPAC Name: 2,2-diphenylacetyl chloride
InChIKey: LVVQRXRVCLWIIO-UHFFFAOYSA-N
SMILES: O=C(CN(CCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C(CN4C=NC5=C4N=CN=C5NC(OC(C6=CC=CC=C6)C7=CC=CC=C7)=O)=O)O
Biological Activity:
Fmoc-PNA-A(Bhoc)-OH is a protected peptide nucleic acid (PNA) monomer carrying an adenine base. Fmoc-PNA-A(Bhoc)-OH contains Fmoc and benzhydryloxycarbonyl (Bhoc) protecting groups, and serves as a standard building block designed specifically for solid-phase PNA synthesis. Fmoc-PNA-A(Bhoc)-OH can be efficiently used to synthesize PNA-based sequence-specific hybridization probes. These probes have broad applications in molecular biology research; for example, they can be used in HER2-expressing tumor-related studies, providing tools for disease diagnosis and mechanism exploration[1][2][3].
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Fmoc-PNA-A(Bhoc)-OH | Fmoc-PNA-A(Bhoc)-OH is a protected peptide nucleic acid (PNA) monomer carrying an adenine base. Fmoc-PNA-A(Bhoc)-OH contains Fmoc and benzhydryloxycarbonyl (Bhoc) protecting groups, and serves as a standard building block designed specifically for solid-phase PNA synthesis. Fmoc-PNA-A(Bhoc)-OH can be efficiently used to synthesize PNA-based sequence-specific hybridization probes. These probes have broad applications in molecular biology research; for example, they can be used in HER2-expressing tumor-related studies, providing tools for disease diagnosis and mechanism exploration. |
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References
- [1]. Petkowski JJ, et al. Astrobiological implications of the stability and reactivity of peptide nucleic acid (PNA) in concentrated sulfuric acid. Sci Adv. 2025;11(13):eadr0006. [Content Brief]
- [2]. Yagita R, Murakami K, Ikeda H, et al. Synthesis and physicochemical properties of 20-mer peptide nucleic acid conjugates with testosterone 17β-carboxylic acid[J]. Tetrahedron Letters, 2020, 61(17): 151781.
- [3]. Westerlund K, et al. Design, Preparation, and Characterization of PNA-Based Hybridization Probes for Affibody-Molecule-Mediated Pretargeting. Bioconjug Chem. 2015;26(8):1724-1736. [Content Brief]
