186299-34-3
186299-34-3
Chemical Structure
EUK-118
- CAS No.: 186299-34-3
- Formula:C22H25MnN2O8
- Molecular Weight:500.38
InChIKey: HBERMORFIFQRRW-AIMLMLFYSA-K
SMILES: CC([O-][Mn+3]123[N](CC[N]2=CC4=C(OC)C=C(OC)C=C4[O-]3)=CC5=C(C=C(OC)C=C5OC)[O-]1)=O
Biological Activity: EUK-118 is an analog of EUK 8 and EUK 134 with reduced activity. EUK-118 exhibits superoxide dismutase (SOD) mimetic activity[1][2].
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EUK-118 | EUK-118 is an analog of EUK 8 and EUK 134 with reduced activity. EUK-118 exhibits superoxide dismutase (SOD) mimetic activity. | |||||||||||||||||||||
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References
- [1]. Doctrow SR, et, al. Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies. J Med Chem. 2002 Sep 26;45(20):4549-58. [Content Brief]
- [2]. Vera M, et, al. Antioxidant and Anti-Inflammatory Strategies Based on the Potentiation of Glutathione Peroxidase Activity Prevent Endothelial Dysfunction in Chronic Kidney Disease. Cell Physiol Biochem. 2018;51(3):1287-1300. [Content Brief]
