1863978-06-6
1863978-06-6
Chemical Structure
C14-Tri-LAN-Gly
- CAS No.: 1863978-06-6
- Formula:C30H53N5O10S
- Molecular Weight:675.83
InChIKey: ZEHVFHODMUIWTR-AFXVXQJMSA-N
SMILES: CCCCCCCCCCCCCC(N[C@@H](C)C(N[C@@H](C(O)=O)CCC(N[C@@H](CSC[C@@H](N)C(O)=O)C(NCC(O)=O)=O)=O)=O)=O
Biological Activity: C14-Tri-LAN-Gly is a highly selective and potent NOD1 agonist. C14-Tri-LAN-Gly activates NOD1. C14-Tri-LAN-Gly inhibits the expression of cleaved-caspase3. C14-Tri-LAN-Gly upregulates A20 expression. C14-Tri-LAN-Gly protects mice from lethal hepatitis by inhibiting hepatocyte Apoptosis. C14-Tri-LAN-Gly inhibits osteoblastogenesis and promots osteoclastogenesis[1][2].
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C14-Tri-LAN-Gly | C14-Tri-LAN-Gly is a highly selective and potent NOD1 agonist. C14-Tri-LAN-Gly activates NOD1. C14-Tri-LAN-Gly inhibits the expression of cleaved-caspase3. C14-Tri-LAN-Gly upregulates A20 expression. C14-Tri-LAN-Gly protects mice from lethal hepatitis by inhibiting hepatocyte Apoptosis. C14-Tri-LAN-Gly inhibits osteoblastogenesis and promots osteoclastogenesis. | |||||||||||||||||||||
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References
- [1]. Jia F, et al. NOD1 Agonist Protects Against Lipopolysaccharide and D-Galactosamine-Induced Fatal Hepatitis Through the Upregulation of A20 Expression in Hepatocytes. Front Immunol. 2021 Mar 4;12:603192. [Content Brief]
- [2]. Park OJ, et al. The dual roles of peptidoglycans: NOD1 and NOD2 inversely regulate bone metabolism. Exp Mol Med. 2025 Aug;57(8):1837-1846. [Content Brief]
