187389-53-3
187389-53-3
Chemical Structure
Boc-Asp(OMe)-fluoromethyl ketone
Synonym(s): Boc-Asp(OMe)-FMK
- CAS No.: 187389-53-3
- Formula:C11H18FNO5
- Molecular Weight:263.26
IUPAC Name: methyl (S)-3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate
InChIKey: MXOOUCRHWJYCAL-ZETCQYMHSA-N
SMILES: O=C(OC)C[C@H](NC(OC(C)(C)C)=O)C(CF)=O
Biological Activity: Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Boc-Asp(OMe)-fluoromethyl ketone | 98.0% | Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8. | ||||||||||||||||||||
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Boc-Asp(OMe)-fluoromethyl ketone (Standard) | ≥98% | Boc-Asp(OMe)-fluoromethyl ketone (Standard) is the analytical standard of Boc-Asp(OMe)-fluoromethyl ketone (HY-103348). This product is intended for research and analytical applications. Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8. | ||||||||||||||||||||
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References
- [1]. Paunel-Görgülü A, et al. Stimulation of Fas signaling down-regulates activity of neutrophils from major trauma patients with SIRS. Immunobiology. 2011;216(3):334-342. [Content Brief]
- [2]. Koike A, et al. Pan-caspase inhibitors induce necroptosis via ROS-mediated activation of mixed lineage kinase domain-like protein and p38 in classically activated macrophages. Exp Cell Res. 2019;380(2):171-179. [Content Brief]
