1874-54-0
1874-54-0
Chemical Structure
Psicofuranine
- CAS No.: 1874-54-0
- Formula:C11H15N5O5
- Molecular Weight:297.27
IUPAC Name: (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-2,5-bis(hydroxymethyl)tetrahydrofuran-3,4-diol
InChIKey: BNZYRKVSCLSXSJ-IOSLPCCCSA-N
SMILES: OC[C@@H]1[C@H]([C@H]([C@@](CO)(O1)N2C=NC3=C2N=CN=C3N)O)O
Biological Activity: Psicofuramine a nucleoside antibiotic and has the inhibition of xanthosine 5'-phosphate aminase. Psicofuranine also specifically inhibits GMP synthase, and interrupts parasite growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Psicofuranine | 98.0% | Psicofuramine a nucleoside antibiotic and has the inhibition of xanthosine 5'-phosphate aminase. Psicofuranine also specifically inhibits GMP synthase, and interrupts parasite growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth. | ||||||||||||||||||||
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References
- [1]. cConkey GA. Plasmodium falciparum: isolation and characterisation of a gene encoding protozoan GMP synthase. Exp Parasitol. 2000 Jan;94(1):23-32. [Content Brief]
- [2]. UDAKA S, et al. INHIBITION OF PARENTAL AND MUTANT XANTHOSINE 5'-PHOSPHATE AMINASES BY PSICOFURANINE. J Biol Chem. 1963 Aug;238:2797-803. [Content Brief]
