1878200-88-4
1878200-88-4
Chemical Structure
IDO1/TDO-IN-9
- CAS No.: 1878200-88-4
- Formula:C6H3ClFN3O
- Molecular Weight:187.56
IUPAC Name: 6-chloro-5-fluoroisoxazolo[5,4-b]pyridin-3-amine
InChIKey: MTIDNIWREKNKHM-UHFFFAOYSA-N
SMILES: NC1=NOC2=NC(Cl)=C(F)C=C21
Biological Activity: IDO1/TDO-IN-9 (Compound 66) is a potent dual inhibitor targeting indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) with IC50s of <1 μM. IDO1/TDO-IN-9 inhibits the activity of IDO1 and TDO, blocking tryptophan degradation to kynurenine, restoring immune activity in the tumor microenvironment, and suppressing tumor growth. IDO1/TDO-IN-9 is promising for research of cancers[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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IDO1/TDO-IN-9 | 99.54% | IDO1/TDO-IN-9 (Compound 66) is a potent dual inhibitor targeting indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) with IC50s of <1 μM. IDO1/TDO-IN-9 inhibits the activity of IDO1 and TDO, blocking tryptophan degradation to kynurenine, restoring immune activity in the tumor microenvironment, and suppressing tumor growth. IDO1/TDO-IN-9 is promising for research of cancers. | ||||||||||||||||||||
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