188186-61-0
Chemical Structure
SB 247083
- CAS No.: 188186-61-0
- Formula:C34H33ClN2O7
- Molecular Weight:617.09
IUPAC Name: (E)-2-((2-(1-butyl-4-(2-carboxy-3-(5-methoxy-2,3-dihydrobenzofuran-6-yl)prop-1-en-1-yl)-1H-pyrazol-5-yl)-5-chlorophenoxy)methyl)benzoic acid
InChIKey: QVEGXHOZQYEMHS-BUVRLJJBSA-N
SMILES: COC(C=C1C(OCC1)=C2)=C2C/C(C(O)=O)=C\C3=C(C4=C(C=C(C=C4)Cl)OCC5=C(C=CC=C5)C(O)=O)N(N=C3)CCCC
Biological Activity: SB 247083 is a selective, competitive and orally active endothelin-A receptor antagonist with a Ki of 0.41 nM. SB 247083 shows a Ki of 467 nM to endothelin-B receptor. SB 247083 shows a Kb of 3.5 nM for ET-1-induced contraction of rat aorta. SB 247083 can be used for the research of cardiovascular disease[1].
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SB 247083 | SB 247083 is a selective, competitive and orally active endothelin-A receptor antagonist with a Ki of 0.41 nM. SB 247083 shows a Ki of 467 nM to endothelin-B receptor. SB 247083 shows a Kb of 3.5 nM for ET-1-induced contraction of rat aorta. SB 247083 can be used for the research of cardiovascular disease. | |||||||||||||||||||||
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