18829-56-6
Chemical Structure
trans-2-Nonenal
Synonym(s): trans-2-Nonen-1-al
- CAS No.: 18829-56-6
- Formula:C9H16O
- Molecular Weight:140.22
IUPAC Name: (E)-non-2-enal
InChIKey: BSAIUMLZVGUGKX-BQYQJAHWSA-N
SMILES: CCCCCC/C=C/C=O
Biological Activity: trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and 12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc.[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
trans-2-Nonenal | 98.99% | trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and 12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc.. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
trans-2-Nonenal (Standard) | 99.34% | trans-2-Nonenal (Standard) is the analytical standard of trans-2-Nonenal. This product is intended for research and analytical applications. trans-2-Nonenal is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Sakuma S, et al. Effects of nonanal, trans-2-nonenal and 4-hydroxy-2,3-trans-nonenal on cyclooxygenase and 12-lipoxygenase metabolism of arachidonic acid in rabbit platelets. J Pharm Pharmacol. 1997;49(2):150-153. [Content Brief]
- [2]. Ishino K, Wakita C, Shibata T, et al. Lipid peroxidation generates body odor component trans-2-nonenal covalently bound to protein in vivo[J]. Journal of Biological Chemistry, 2010, 285(20): 15302-15313.
- [3]. Nakanishi S, Makita M, Denda M. Effects of trans-2-nonenal and olfactory masking odorants on proliferation of human keratinocytes[J]. Biochemical and biophysical research communications, 2021, 548: 1-6.
