1883548-85-3
1883548-85-3
Chemical Structure
WAY-181187 oxalate
Synonym(s): SAX-187 oxalate
- CAS No.: 1883548-85-3
- Formula:C17H15ClN4O6S2
- Molecular Weight:470.91
IUPAC Name: 2-(1-((6-chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl)-1H-indol-3-yl)ethan-1-amine oxalate
InChIKey: KAFVDFYVWBASDD-UHFFFAOYSA-N
SMILES: O=C(C(O)=O)O.O=S(C1=C(N=C2SC=CN21)Cl)(N3C=C(CCN)C4=C3C=CC=C4)=O
Biological Activity: WAY-181187 (SAX-187) oxalate is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[1][2].
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WAY-181187 oxalate | WAY-181187 (SAX-187) oxalate is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist. | |||||||||||||||||||||
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References
- [1]. Lee E Schechter, et al. Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. [Content Brief]
- [2]. Teresa Riccioni, et al. ST1936 Stimulates cAMP, Ca2+, ERK1/2 and Fyn Kinase Through a Full Activation of Cloned Human 5-HT6 Receptors. Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14. [Content Brief]
